CAS No.3993-78-0 | 2-Amino-4-chloropyrimidine
Name: 2-Amino-4-chloropyrimidine CAS No.3993-78-0 MF: C4H4ClN3 MW: 129.55 Purity:97% Package: 5g,25g,100g,500g,1kg,25kg Worldwide Delivery
Categories：
Analytical Chemicals
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Product introduction
Introduction and application of CAS No.3993-78-0 | 2-Amino-4-chloropyrimidine
2-Amino-4-chloropyrimidine is an amido compound that is used to treat infectious diseases. It is a potent inhibitor of the enzyme topoisomerase II, which is involved in DNA replication and transcription. This drug has shown cytotoxic activity against du145 cells, an immortalized prostate cancer cell line. 2-Amino-4-chloropyrimidine has also been shown to be effective against MDA-MB-231 cells and thp1 cells, which are human breast cancer cell lines. 2-Amino-4-chloropyrimidine binds to the active site of topoisomerase II, preventing the enzyme from binding with the two ends of DNA and causing DNA breakage. The drug has also been shown to inhibit the growth of cervical cancer cells by binding with amine groups on proteins found on these cells.
Specification of CAS No.3993-78-0 | 2-Amino-4-chloropyrimidine
|
CAS No. |
3993-78-0 |
|
MF |
C4H4ClN3 |
|
MW |
129.55 |
|
Melting point |
155-160 °C (dec.) |
|
Boiling point |
314.6±34.0 °C(Predicted) |
|
Density（25℃，g/cm3） |
1.437±0.06 g/cm3(Predicted) |
|
acidity coefficient(pKa) |
3.55±0.10(Predicted) |
Package of CAS No.3993-78-0 | 2-Amino-4-chloropyrimidine
Package:100g; 500g; 1kg; 25kg;bulk package
Transportation: by courier/ by air/ by sea
Related Articles of CAS No.3993-78-0 | 2-Amino-4-chloropyrimidine
Amination of 2-chloro-and 2, 4-dichloropyrimidines by polyamines
AD Averin, OA Ulanovskaya, IP Beletskaya - Chemistry of heterocyclic …, 2008 - Springer
… These data permit us to distinguish between the 2-amino-4-chloropyrimidine and 4-amino-2-…
Thus, for example, this proton in the 2-amino-4-chloropyrimidine ring in compound 12c is …
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